Monoamine Oxidase B inhibitor 4 is a selective inhibitor of human monoamine oxidase-B (hMAO-B), with an IC50 of 8.3 nM. This compound demonstrates anti-neuroinflammatory properties and exhibits low neurotoxicity. Monoamine Oxidase B inhibitor 4 effectively reduces the release of pro-inflammatory cytokines such as NO, TNF-α, and IL-1β in response to LPS and Aβ1-42, while also mitigating Aβ(1-42)-induced cytotoxicity, making it a valuable tool for research in neurodegenerative diseases and neuroinflammation.
Monoamine Oxidase B inhibitor 4 is a selective inhibitor of human monoamine oxidase-B (hMAO-B), with an IC50 of 8.3 nM. This compound demonstrates anti-neuroinflammatory properties and exhibits low neurotoxicity. Monoamine Oxidase B inhibitor 4 effectively reduces the release of pro-inflammatory cytokines such as NO, TNF-α, and IL-1β in response to LPS and Aβ1-42, while also mitigating Aβ(1-42)-induced cytotoxicity, making it a valuable tool for research in neurodegenerative diseases and neuroinflammation.
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