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Monomethyl auristatin E intermediate-16

Intermediate Reactant

Monomethyl auristatin E intermediate-16 is an essential intermediate reagent in the synthesis of Monomethyl auristatin E (MMAE), a potent microtubule/tubulin inhibitor exhibiting notable anticancer activity. MMAE serves as a key cytotoxic component in antibody-drug conjugates (ADCs), enabling targeted delivery of therapeutic agents to cancer cells. This compound is crucial for researchers exploring the development and optimization of novel ADCs in cancer therapeutics.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2380991-16-0
Applications	Intermediate Reactant
Formula	C₂₀H₂₉NO₅
Molecular Weight	363.45
SMILES	O[C@@H]([C@H](C)C(OCC1=CC=CC=C1)=O)[C@@H]2N(C(OC(C)(C)C)=O)CCC2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.