MRK 560

Catalog No.: A15304

γ-secretase inhibitor

MRK 560

MRK 560 Chemical Structure

CAS NO. 677772-84-8

MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.

Availability: In stock

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10 mg
$170.00
50 mg
$760.00
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Biological Activity

MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.31 mL 96.54 mL 193.08 mL
0.5 mM 3.86 mL 19.31 mL 38.62 mL
1 mM 1.93 mL 9.65 mL 19.31 mL
5 mM 0.39 mL 1.93 mL 3.86 mL

*The above data is based on the productmolecular weight 517.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A15304
Actions Inhibitor
CAS No. 677772-84-8
Formula C19H17ClF5NO4S2
M. Wt 517.92
Solubility DMSO
Purity >98%
Synonyms MRK-560, MRK560
SMILES C1CC(CCC1NS(=O)(=O)C(F)(F)F)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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