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MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.31 mL | 96.54 mL | 193.08 mL |
| 0.5 mM | 3.86 mL | 19.31 mL | 38.62 mL |
| 1 mM | 1.93 mL | 9.65 mL | 19.31 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
*The above data is based on the productmolecular weight 517.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A15304 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 677772-84-8 |
| Formula | C19H17ClF5NO4S2 |
| M. Wt | 517.92 |
| Solubility | DMSO |
| Purity | >98% |
| Synonyms | MRK-560, MRK560 |
| SMILES | C1CC(CCC1NS(=O)(=O)C(F)(F)F)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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