MRK 560

Catalog No.: A15304

γ-secretase inhibitor

MRK 560

MRK 560 Chemical Structure

CAS NO. 677772-84-8

MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.

Availability: In stock

Package Price Qty
10 mg
$170.00
50 mg
$760.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 19.31 mL 96.54 mL 193.08 mL
0.5 mM 3.86 mL 19.31 mL 38.62 mL
1 mM 1.93 mL 9.65 mL 19.31 mL
5 mM 0.39 mL 1.93 mL 3.86 mL

*The above data is based on the productmolecular weight 517.92. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A15304
Actions Inhibitor
M. Wt 517.92
Formula C19H17ClF5NO4S2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 677772-84-8
Synonyms MRK-560, MRK560
SMILES C1CC(CCC1NS(=O)(=O)C(F)(F)F)(C2=C(C=CC(=C2)F)F)S(=O)(=O)C3=CC=C(C=C3)Cl

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