MRL-871 is a potent allosteric inverse agonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an IC50 of 12.7 nM. This compound is characterized by its unique isoxazole chemotype and demonstrates significant efficacy in reducing IL-17a mRNA production in EL4 cells. MRL-871 is useful for research applications focused on immune response modulation and studying the role of RORγt in autoimmune diseases.
MRL-871 is a potent allosteric inverse agonist of the retinoic acid receptor-related orphan receptor γt (RORγt), exhibiting an IC50 of 12.7 nM. This compound is characterized by its unique isoxazole chemotype and demonstrates significant efficacy in reducing IL-17a mRNA production in EL4 cells. MRL-871 is useful for research applications focused on immune response modulation and studying the role of RORγt in autoimmune diseases.
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