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MS-377

Sigma-1 Receptor Ligand

MS-377 is a selective sigma-1 receptor ligand with an affinity (Ki = 73 nM) that demonstrates minimal interaction with the sigma-2 receptor (Ki = 6900 nM) and no significant binding to other receptors, including those for dopamine and serotonin. This compound indirectly modulates the NMDA receptor ion-channel complex, exhibiting antipsychotic activity by inhibiting PCP-induced behaviors and reducing dopamine and serotonin release in the rat medial prefrontal cortex. MS-377 is suitable for research applications related to schizophrenia.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	206862-30-8
Applications	Sigma-1 Receptor Ligand
Formula	C₁₈H₂₆ClN₃O₂
Molecular Weight	351.87
SMILES	O=C1N(C2=CC=C(Cl)C=C2)CC[C@@H]1CN3CCN(CCOC)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.