Fig. 1 · Structure
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Ms-PEG2-C2-Boc
PROTAC Linker
Ms-PEG2-C2-Boc is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates the conjugation of E3 ligases to target proteins, thereby promoting ubiquitination and subsequent degradation of specific intracellular targets. The incorporation of Ms-PEG2-C2-Boc into PROTAC development enables the modulation of protein levels, making it a valuable tool for targeted protein degradation studies and related therapeutic research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1312309-62-8 |
| Applications | PROTAC Linker |
| Formula | C12H24O7S |
| Molecular Weight | 312.38 |
| SMILES | CS(OCCOCCOCCC(OC(C)(C)C)=O)(=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.