MS049 dihydrochloride is a selective inhibitor of protein arginine methyltransferases PRMT4 and PRMT6, demonstrating IC50 values of 34 nM and 43 nM, respectively. This compound effectively reduces the levels of dimethylated Med12 and H3R2 in HEK293 cells, making it valuable for studying the role of arginine methylation in cellular processes. MS049 dihydrochloride shows low toxicity and does not adversely affect cell proliferation, offering a reliable tool for research into epigenetic regulation and associated pathways.
MS049 dihydrochloride is a selective inhibitor of protein arginine methyltransferases PRMT4 and PRMT6, demonstrating IC50 values of 34 nM and 43 nM, respectively. This compound effectively reduces the levels of dimethylated Med12 and H3R2 in HEK293 cells, making it valuable for studying the role of arginine methylation in cellular processes. MS049 dihydrochloride shows low toxicity and does not adversely affect cell proliferation, offering a reliable tool for research into epigenetic regulation and associated pathways.
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