MS143 is a potent PROTAC degrader targeting AKT, demonstrating a DC50 of 46 nM and GI50 of 0.8 μM in PC3 cells. This compound effectively induces rapid and robust AKT degradation through the hijacking of the ubiquitin-proteasome system in a concentration- and time-dependent manner. MS143 holds promise in cancer research for its ability to suppress cell growth by promoting targeted protein degradation.
MS143 is a potent PROTAC degrader targeting AKT, demonstrating a DC50 of 46 nM and GI50 of 0.8 μM in PC3 cells. This compound effectively induces rapid and robust AKT degradation through the hijacking of the ubiquitin-proteasome system in a concentration- and time-dependent manner. MS143 holds promise in cancer research for its ability to suppress cell growth by promoting targeted protein degradation.
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