mTOR inhibitor-11

Catalog No.: A79736
mTOR Inhibitor
mTOR Inhibitor-11 is a potent inhibitor of the mechanistic target of rapamycin (mTOR), exhibiting an IC50 of 21 nM for phosphorylated S6 ribosomal protein. This compound also demonstrates inhibitory activity against checkpoint kinase 1 (pCHK1) and phosphodiesterase 4D (PDE4D), with IC50 values of 17.2 μM and 17.0 μM, respectively. mTOR Inhibitor-11 is suitable for research on central nervous system (CNS) diseases, facilitating studies into neurodegenerative conditions and other related disorders.
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Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionmTOR Inhibitor-11 is a potent inhibitor of the mechanistic target of rapamycin (mTOR), exhibiting an IC50 of 21 nM for phosphorylated S6 ribosomal protein. This compound also demonstrates inhibitory activity against checkpoint kinase 1 (pCHK1) and phosphodiesterase 4D (PDE4D), with IC50 values of 17.2 μM and 17.0 μM, respectively. mTOR Inhibitor-11 is suitable for research on central nervous system (CNS) diseases, facilitating studies into neurodegenerative conditions and other related disorders.
Product Information
Catalog NumA79736
FormulaC21H26N6O2
Molecular Weight394.47
CAS Number3033409-32-1
SMILESC[C@@H]1COCCN1C2=C3N=C(C4=NC=CC=C4)NC3=NC(N5[C@@H](C)COCC5)=C2
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