mTOR inhibitor-23 (compound DHM25) is a selective and irreversible covalent inhibitor of the mechanistic target of rapamycin (mTOR). It functions through covalent interaction with a nucleophilic amino acid in the ATP binding pocket, effectively modulating mTOR signaling pathways. This compound demonstrates significant antitumor activity against triple-negative breast cancer cell lines, highlighting its potential in cancer research and therapeutic applications.
mTOR inhibitor-23 (compound DHM25) is a selective and irreversible covalent inhibitor of the mechanistic target of rapamycin (mTOR). It functions through covalent interaction with a nucleophilic amino acid in the ATP binding pocket, effectively modulating mTOR signaling pathways. This compound demonstrates significant antitumor activity against triple-negative breast cancer cell lines, highlighting its potential in cancer research and therapeutic applications.
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