MTX-216

Name: MTX-216
Brand: Adooq Bioscience
SKU: A33147
Rating: 5 (288 reviews)

Catalog No.: A33147

PI3K/EGFR Inhibitor

MTX-216 is a dual ATP-competitive inhibitor targeting PI3K and EGFR. It effectively cosuppresses Ki-67 and phosphorylation of ribosomal S6, leading to apoptosis in NF1LOF cells. Additionally, MTX-216 inhibits SYK kinase activity with an IC50 of 281 nM. This compound is primarily utilized in research related to melanoma.

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MTX-216 1952236-19-9 PI3K/EGFR Inhibitor

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Biological Activity

Description	MTX-216 is a dual ATP-competitive inhibitor targeting PI3K and EGFR. It effectively cosuppresses Ki-67 and phosphorylation of ribosomal S6, leading to apoptosis in NF1LOF cells. Additionally, MTX-216 inhibits SYK kinase activity with an IC50 of 281 nM. This compound is primarily utilized in research related to melanoma.

Product Information

Catalog Num	A33147
Formula	C22H14Cl2FN5O2S
Molecular Weight	502.35
CAS Number	1952236-19-9
SMILES	N#CC1=C(NC2=CC=C(C(Cl)=C2)F)C3=CC(C4=CC(NS(=O)(C)=O)=C(Cl)N=C4)=CC=C3N=C1

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