Fig. 1 · Structure
Documents & Downloads
MTX115325
USP30 Inhibitor
MTX115325 is a potent USP30 inhibitor with an IC50 value of 12 nM, demonstrating oral bioavailability and effective brain penetration. This compound enhances the ubiquitination of the mitochondrial outer membrane protein TOM20, a substrate of USP30, at an EC50 of 32 nM, thereby promoting mitophagy. MTX115325 exhibits neuroprotective properties by preventing the loss of dopaminergic neurons and preserving striatal dopamine levels, making it a valuable tool for research in neurodegenerative diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2750895-97-5 |
| Applications | USP30 Inhibitor |
| Formula | C18H16N6O2 |
| Molecular Weight | 348.36 |
| SMILES | O=C(C1=NC=C(C2=CC=NC(C#N)=C2)O1)N3[C@]4([H])[C@@](CC3)([H])[C@H](N(C4)C#N)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.