Fig. 1 · Structure
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Muvalaplin
Lp (a) Inhibitor
Muvalaplin is an orally active, selective inhibitor of lipoprotein (a) (Lp(a)), targeting the non-covalent interaction between apolipoprotein(a) and apolipoprotein B100. By preventing the formation of disulfide bonds, Muvalaplin effectively reduces Lp(a) levels, as demonstrated in transgenic mouse models and cynomologus monkeys. This compound holds significant potential for research into cardiovascular diseases and dyslipidemia related to elevated Lp(a) levels.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2565656-70-2 |
| Applications | Lp (a) Inhibitor |
| Formula | C42H54N4O6 |
| Molecular Weight | 710.90 |
| Synonyms | LY3473329 |
| SMILES | OC([C@H]([C@H]1CCNC1)CC2=CC(CN(CC3=CC(C[C@@H]([C@H]4CCNC4)C(O)=O)=CC=C3)CC5=CC(C[C@@H]([C@H]6CCNC6)C(O)=O)=CC=C5)=CC=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.