Fig. 1 · Structure
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N-Acetyl-4-S-cysteaminylphenol
DNA/RNA Synthesi Inhibitor
N-Acetyl-4-S-cysteaminylphenol is a targeted DNA/RNA synthesis inhibitor with selective cytotoxicity towards melanocytes, particularly in black mouse hair follicles. This compound induces significant depigmentation, leading to up to 98% depigmentation due to its ability to initiate melanin granule aggregation and nuclear condensation within hours of administration. Observations via electron microscopy reveal progressive destruction of melanocytes characterized by organelle swelling, nuclear condensation, and cytoplasmic vacuolation, culminating in complete cell necrosis. Given its specific activity against eumelanin-producing melanocytes, N-Acetyl-4-S-cysteaminylphenol holds potential for therapeutic applications in melanoma treatment and skin whitening strategies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 91281-32-2 |
| Applications | DNA/RNA Synthesi Inhibitor |
| Formula | C10H13NO2S |
| Molecular Weight | 211.28 |
| Synonyms | N-Ac-4-S-CAP |
| SMILES | O=C(NCCSC1=CC=C(O)C=C1)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.