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N-(Azido-PEG4)-N-Boc-PEG4-Boc

PROTAC linker

N-(Azido-PEG4)-N-Boc-PEG4-Boc is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an azide moiety, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with alkyne-containing substrates. Additionally, it is suitable for strain-promoted alkyne-azide cycloaddition (SPAAC) with trans-cyclooctene derivatives, allowing for versatile conjugation strategies in chemical biology studies.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2112737-20-7
Applications	PROTAC linker
Formula	C₃₀H₅₈N₄O₁₂
Molecular Weight	666.80
SMILES	O=C(OC(C)(C)C)N(CCOCCOCCOCCOCCN=[N+]=[N-])CCOCCOCCOCCOCCC(OC(C)(C)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.