Fig. 1 · Structure
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N-Boc-N-bis(PEG2-propargyl)
PROTAC linker
N-Boc-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules. Its utility in facilitating targeted protein degradation makes it valuable for research in drug discovery and development, particularly in studies aimed at modulating protein levels within biological systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2100306-86-1 |
| Applications | PROTAC linker |
| Formula | C19H31NO6 |
| Molecular Weight | 369.45 |
| SMILES | O=C(OC(C)(C)C)N(CCOCCOCC#C)CCOCCOCC#C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.