N-Desmethyl topotecan-d3 hydrochloride

Catalog No.: B13940
Isotope-Labeled Compounds
N-Desmethyl topotecan-d3 is a deuterium-labeled analog of N-Desmethyl topotecan, primarily used in isotope labeling applications. This compound retains the biological activity of the original molecule, which acts as a topoisomerase I inhibitor, disrupting DNA replication and transcription processes. It is suitable for kinetic studies, metabolic profiling, and pharmacokinetic research to enhance the understanding of drug metabolism and efficacy.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionN-Desmethyl topotecan-d3 is a deuterium-labeled analog of N-Desmethyl topotecan, primarily used in isotope labeling applications. This compound retains the biological activity of the original molecule, which acts as a topoisomerase I inhibitor, disrupting DNA replication and transcription processes. It is suitable for kinetic studies, metabolic profiling, and pharmacokinetic research to enhance the understanding of drug metabolism and efficacy.
Product Information
Catalog NumB13940
FormulaC22H19D3ClN3O5
Molecular Weight446.90
CAS Number2701830-42-2
SMILESCC[C@@]1(C2=C(COC1=O)C(N3C(C(C(C3)=CC4=C5CNC([2H])([2H])[2H])=NC4=CC=C5O)=C2)=O)O.Cl
Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C1V1 = C2V2

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