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N-Desthiobiotin-N-bis(PEG4-t-butyl ester)

PROTAC Linkers

N-Desthiobiotin-N-bis(PEG4-t-butyl ester) is a polyethylene glycol (PEG)-based linker designed for use in PROTAC (proteolysis-targeting chimeras) synthesis. This compound facilitates the selective degradation of target proteins by linking ligands to E3 ligases, thereby enhancing the potency and selectivity of PROTAC molecules. It is an essential tool for researchers studying targeted protein degradation and its therapeutic potential in various biological applications.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2353409-60-4
Applications	PROTAC Linkers
Formula	C₄₀H₇₅N₃O₁₄
Molecular Weight	822.04
SMILES	C[C@H](N1)[C@H](NC1=O)CCCCCC(N(CCOCCOCCOCCOCCC(OC(C)(C)C)=O)CCOCCOCCOCCOCCC(OC(C)(C)C)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.