Fig. 1 · Structure
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N-Didesmethyl Loperamide
PET radiotracer
N-Didesmethyl Loperamide is a metabolite of Loperamide and serves as an innovative PET radiotracer specifically designed for visualizing P-glycoprotein (P-gp) function in vivo. This compound contributes to the understanding of drug transport mechanisms and can enhance insights into multidrug resistance in various diseases, particularly in cancer research. Its application in PET imaging provides valuable information for both pharmacological studies and the development of therapeutic strategies targeting P-gp.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 66164-06-5 |
| Applications | PET radiotracer |
| Formula | C27H29ClN2O2 |
| Molecular Weight | 448.98 |
| Synonyms | R 21345 |
| SMILES | O=C(C(C1=CC=CC=C1)(CCN2CCC(C3=CC=C(C=C3)Cl)(CC2)O)C4=CC=CC=C4)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.