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N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5

PROTAC linker

N-methyl-N'-methyl-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 functions as a PEG-based PROTAC linker, facilitating the synthesis of heterobifunctional protein-targeting chimeras. This compound features an azide group, enabling its use in click chemistry through copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-bearing molecules. Additionally, it can participate in strain-promoted alkyne-azide cycloaddition (SPAAC) with DBCO or BCN groups, making it suitable for advanced applications in chemical biology and targeted protein degradation research.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2107273-56-1
Applications	PROTAC linker
Formula	C₄₆H₆₈ClN₅O₁₀
Molecular Weight	886.51
SMILES	COCCOCCOCCOCCOC1=CC2=C([N+](C)=C(/C=C/C=C/C=C3N(C)C4=C(C=C(OCCOCCOCCOCCOCCN=[N+]=[N-])C=C4)C\3(C)C)C2(C)C)C=C1.[Cl-]

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.