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N,O-Didansyl-L-tyrosine cyclohexylammonium

Thymidylate Synthase Inhibitor

N,O-Didansyl-L-tyrosine cyclohexylammonium is a selective inhibitor of thymidylate synthase (TS), effectively targeting TS in Escherichia coli, Lactobacillus casei, and human cells. It demonstrates potent inhibitory activity with IC50 values of 5.0 μM for E. coli, 3.4 μM for L. casei, and 119 μM for human TS. This compound serves as a valuable tool for studying thymidylate synthase in various biochemical and pharmaceutical research applications.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	102783-47-1
Applications	Thymidylate Synthase Inhibitor
Formula	C₃₉H₄₆N₄O₇S₂
Molecular Weight	746.94
SMILES	NC1CCCCC1.CN(C)c1cccc2c(cccc12)S(=O)(=O)N[C@@H](Cc1ccc(OS(=O)(=O)c2cccc3c(cccc23)N(C)C)cc1)C(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.