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N-(PEG2-C2-acid)-N-bis(PEG2-propargyl)

PROTAC linker

N-(PEG2-C2-acid)-N-bis(PEG2-propargyl) is a PEG-based PROTAC linker designed for the efficient synthesis of targeted protein degraders. This compound features an alkyne functional group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc), allowing for precise conjugation with azide-containing molecules. Its innovative design enhances solubility and biocompatibility, making it suitable for various biochemical applications in drug discovery and chemical biology.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2100306-49-6
Applications	PROTAC linker
Formula	C₂₁H₃₅NO₈
Molecular Weight	429.50
SMILES	C#CCOCCOCCN(CCOCCOCC#C)CCOCCOCCC(O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.