N1-Methyl-5-methyl ara-uridine

Catalog No.: A56215
Purine Nucleoside Analog
N1-Methyl-5-methyl ara-uridine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. This compound exerts its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. Its application in research includes studying potential therapeutic strategies for lymphoid cancers and examining the underlying mechanisms of nucleoside analog efficacy in tumor cell lines.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionN1-Methyl-5-methyl ara-uridine is a purine nucleoside analog known for its broad antitumor activity, particularly against indolent lymphoid malignancies. This compound exerts its anticancer effects primarily through the inhibition of DNA synthesis and the induction of apoptosis. Its application in research includes studying potential therapeutic strategies for lymphoid cancers and examining the underlying mechanisms of nucleoside analog efficacy in tumor cell lines.
Product Information
Catalog NumA56215
FormulaC11H16N2O6
Molecular Weight272.25
CAS Number887113-66-8
SMILESO=C(C(C)=CN1[C@H]2[C@@H](O)[C@H](O)[C@@H](CO)O2)N(C)C1=O
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