Fig. 1 · Structure

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N2-Isobutyryl-2'-O-methylguanosine

Nucleic acid Synthesis Intermediate

N2-Isobutyryl-2'-O-methylguanosine is a nucleic acid synthesis intermediate crucial for the preparation of antisense oligonucleotides and mRNA modifications. This compound serves as a key monomer for synthesizing 2'-O-methyl oligoribonucleotides, enhancing the stability of the resulting double-stranded structures with complementary RNA and increasing resistance to nuclease degradation. N2-Isobutyryl-2'-O-methylguanosine is primarily utilized in molecular biology research, including the development of RNA hybridization probes and investigations into pre-mRNA splicing mechanisms.

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Specifications

Manufacturer Adooq Bioscience
CAS Number 63264-29-9
Applications Nucleic acid Synthesis Intermediate
Formula C15H21N5O6
Molecular Weight 367.36
SMILES
OC[C@@H]1[C@@H](O)[C@@H](OC)[C@H](N2C=NC3=C2NC(NC(C(C)C)=O)=NC3=O)O1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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