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NAE-IN-3

NAE Inhibitor

NAE-IN-3 is a potent and selective non-covalent inhibitor of the NEDD8-activating enzyme (NAE), demonstrating an IC50 of 0.8 μM. This compound functions by competitively obstructing the ATP-binding domain of NAE, thereby impeding its activity. With a specific focus on NAE, NAE-IN-3 shows minimal interaction with analogous E1 enzymes such as UAE and SAE. This inhibitor is valuable for research aimed at understanding cancer biology and the role of NEDD8 modifications in oncogenesis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	951950-33-7
Applications	NAE Inhibitor
Formula	C₁₇H₁₈N₄O₆
Molecular Weight	374.35
SMILES	O=C(CNC(CNC(COC1=CC2=C(N=C3N(CCC3)C2=O)C=C1)=O)=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.