NAS-181 dimesylate is a selective antagonist of the rat 5-HT1B receptor, exhibiting a Ki value of 47 nM. With a notable 13-fold selectivity for the r5-HT1B receptor compared to the bovine equivalent (Ki=630 nM), NAS-181 effectively enhances serotonin (5-HT) turnover and improves synaptic 5-HT concentration by blocking terminal r5-HT1B autoreceptors. This compound is valuable for research involving serotonin modulation and related neuropharmacological studies.
NAS-181 dimesylate is a selective antagonist of the rat 5-HT1B receptor, exhibiting a Ki value of 47 nM. With a notable 13-fold selectivity for the r5-HT1B receptor compared to the bovine equivalent (Ki=630 nM), NAS-181 effectively enhances serotonin (5-HT) turnover and improves synaptic 5-HT concentration by blocking terminal r5-HT1B autoreceptors. This compound is valuable for research involving serotonin modulation and related neuropharmacological studies.
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