Fig. 1 · Structure
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NAS-181 free base
Rat 5-HT1B Antagonist
NAS-181 free base is a potent and selective antagonist of the rat 5-HT1B receptor, exhibiting a Ki value of 47 nM. This compound demonstrates a 13-fold selectivity for the rat 5-HT1B over the bovine 5-HT1B receptor, which has a Ki of 630 nM. NAS-181 free base effectively enhances serotonin turnover and increases synaptic serotonin levels by inhibiting the terminal rat 5-HT1B autoreceptors, making it a valuable tool for research in neuropharmacology and serotonergic signaling.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 205242-61-1 |
| Applications | Rat 5-HT1B Antagonist |
| Formula | C19H26N2O4 |
| Molecular Weight | 346.42 |
| SMILES | [C@@H]1(CNCCO1)COC2=C3C(C=C(CO3)CN4CCOCC4)=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.