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Natalizumab
Natalizumab is a recombinant, humanized IgG4 monoclonal antibody that targets α4β1-integrin, effectively inhibiting its interaction with vascular cell adhesion molecule-1 (VCAM-1). This antibody is utilized in the management of relapsing-remitting multiple sclerosis and Crohn's disease. It represents the inaugural targeted therapeutic approach that impedes lymphocyte migration into the central nervous system (CNS), thereby preventing acute demyelinating episodes.
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Biological Activity
Product Details
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 189261-10-7 |
Storage
Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.