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Natalizumab

Natalizumab is a recombinant, humanized IgG4 monoclonal antibody that targets α4β1-integrin, effectively inhibiting its interaction with vascular cell adhesion molecule-1 (VCAM-1). This antibody is utilized in the management of relapsing-remitting multiple sclerosis and Crohn's disease. It represents the inaugural targeted therapeutic approach that impedes lymphocyte migration into the central nervous system (CNS), thereby preventing acute demyelinating episodes.

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Biological Activity

Target & Activity

α4β1

Product Details

Manufacturer Adooq Bioscience
CAS Number 189261-10-7

Storage

Store lyophilized at -20°C, keep desiccated.
In lyophilized form, the antibody is stable for 36 months.
After reconstitution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

Customer Questions
Biosimilar antibodies are research-grade recombinant antibodies designed to closely resemble approved therapeutic antibodies in terms of amino acid sequence, structural characteristics, and biological activity. These antibodies are generated using recombinant expression technologies and retain the same variable regions as their corresponding reference therapeutics, thereby preserving target specificity and binding affinity. Owing to these properties, biosimilar antibodies serve as reliable and cost-effective research reagents for applications in drug discovery, pharmacological studies, and basic biomedical research. Research-grade biosimilar antibodies have been successfully expressed and functionally validated against a wide range of widely studied targets. These antibodies can be directly utilized as positive control reagents in drug discovery programs, as well as reference tools for rapid verification of the biological functions of target proteins in biochemical and cellular assays.
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