Fig. 1 · Structure
Documents & Downloads
NBC19
NLRP3 inflammasome Inhibitor
NBC19 is an inhibitor of the NLRP3 inflammasome, exhibiting an IC50 of 60 nM in differentiated THP1 cells. This compound effectively inhibits IL-1β release triggered by nigericin and ATP, with IC50 values of 80 nM and 850 nM, respectively. NBC19 serves as a valuable tool for investigating the role of the NLRP3 inflammasome in inflammatory processes and related research applications.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2068818-75-5 |
| Applications | NLRP3 inflammasome Inhibitor |
| Formula | C24H26BCl3N2O2 |
| Molecular Weight | 491.65 |
| SMILES | O=C(C)C1=C(C(Cl)(Cl)Cl)N[B-](C2=CC=CC=C2)(C3=CC=CC=C3)[O+]=C1NC4CCCCC4 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.