NBC19 is an inhibitor of the NLRP3 inflammasome, exhibiting an IC50 of 60 nM in differentiated THP1 cells. This compound effectively inhibits IL-1β release triggered by nigericin and ATP, with IC50 values of 80 nM and 850 nM, respectively. NBC19 serves as a valuable tool for investigating the role of the NLRP3 inflammasome in inflammatory processes and related research applications.
NBC19 is an inhibitor of the NLRP3 inflammasome, exhibiting an IC50 of 60 nM in differentiated THP1 cells. This compound effectively inhibits IL-1β release triggered by nigericin and ATP, with IC50 values of 80 nM and 850 nM, respectively. NBC19 serves as a valuable tool for investigating the role of the NLRP3 inflammasome in inflammatory processes and related research applications.
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