Fig. 1 · Structure
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NBI-27914 hydrochloride
CRF1 Receptor Antagonist
NBI-27914 hydrochloride is a selective antagonist of the Corticotropin-Releasing Factor 1 (CRF1) receptor, exhibiting a Ki value of 1.7 nM. This compound plays a significant role in the study of stress-related disorders and anxiety, making it a valuable tool for researchers investigating the modulation of CRF1 receptor activity in various biological contexts. Its specificity and potency allow for detailed exploration of CRF1-mediated pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1215766-76-9 |
| Applications | CRF1 Receptor Antagonist |
| Formula | C18H21Cl5N4 |
| Molecular Weight | 470.65 |
| SMILES | CCCN(C1=NC(C)=NC(NC2=C(C=C(Cl)C=C2Cl)Cl)=C1Cl)CC3CC3.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.