Fig. 1 · Structure
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NCATS-SM1441
LDH Inhibitor
NCATS-SM1441 is a potent lactate dehydrogenase (LDH) inhibitor with an IC50 value of 40 nM. By effectively inhibiting LDH activity, NCATS-SM1441 reduces lactic acid production in cancer cells, which may hinder their proliferation. This compound is valuable for investigations into cancer metabolism and therapeutic strategies targeting metabolic pathways in oncological research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1964517-04-1 |
| Applications | LDH Inhibitor |
| Formula | C31H25FN4O4S3 |
| Molecular Weight | 632.75 |
| SMILES | O=C(C1=CSC(N2N=C(C(CC3=CC=C(S(=O)(N)=O)C(F)=C3)=C2CC4CC4)C5=CC(C#CC6=CC=C(C)S6)=CC=C5)=N1)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.