Fig. 1 · Structure
Documents & Downloads
NCB-0970
Inactive Control
NCB-0970 serves as the inactive control for NCB-0846, a selective inhibitor targeting Traf2- and Nck-interacting kinase (TNIK) with an IC50 of 21 nM. While NCB-0846 effectively disrupts the TGF-β signaling pathway by blocking SMAD2/3 phosphorylation and nuclear translocation, NCB-0970 is utilized in research to validate experimental findings and ensure specificity of the active compound. Its application is essential for distinguishing between specific biological responses and non-target effects in studies involving Wnt signaling modulation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2749881-54-5 |
| Applications | Inactive Control |
| Formula | C21H21N5O2 |
| Molecular Weight | 375.42 |
| SMILES | O[C@H](CC1)CC[C@@H]1OC2=CC=CC3=C2N=C(NC4=CC=C(N=CN5)C5=C4)N=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.