Fig. 1 · Structure
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NCI677397
USP24 Inhibitor
NCI677397 is a potent USP24 inhibitor that promotes lipid ROS accumulation and stimulates cholesterol and fatty acid biosynthesis. It facilitates the degradation of ABC transporters, GPX4, and DHFR via autophagy, resulting in decreased levels of P-glycoprotein and triggering ferroptosis in drug-resistant cancer cells. This compound is particularly valuable in research focused on lung and brain cancer therapeutics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 907547-06-2 |
| Applications | USP24 Inhibitor |
| Formula | C28H31N3OS |
| Molecular Weight | 457.63 |
| SMILES | O=C(C1=CC=C2SC3=C(N(CCCCN4CCN(CC4)C)C2=C1)C=CC=C3)C5=CC=CC=C5 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.