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NDM-1-IN-10

NDM-1 Inhibitor

NDM-1-IN-10 is a potent irreversible and covalent inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1), demonstrating an IC50 of 36 nM. This compound exhibits synergistic effects with Meropenem against NDM-1-expressing E. coli, with an observed MIC of 0.25 μg/mL for E. coli BL21/pET15b-blaNDM-1. NDM-1-IN-10 serves as a valuable tool for research focused on bacterial infections and mechanisms of antibiotic resistance.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3044733-61-8
Applications	NDM-1 Inhibitor
Formula	C₁₈H₁₁NaO₆S₃
Molecular Weight	442.46
SMILES	O=S(C(C1=COC2=C(C=CC(SC3=CC4=CC=CC=C4S3)=C2)C1=O)O)(O[Na])=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.