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Necrostatin-21

Necroptosis Inhibitor

Necrostatin-21 is a potent necroptosis inhibitor targeting receptor-interacting protein kinase 1 (RIP1) and c-Jun N-terminal kinase 3 (JNK3) with an EC50 of 0.5 μM. This compound demonstrates an ability to modulate cell death pathways, making it valuable for research into various conditions including infections, cardiovascular diseases, and neurodegenerative disorders such as Alzheimer’s disease. Its dual action on key kinases provides insight into the mechanisms underlying necroptosis and potential therapeutic approaches.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	169136-33-8
Applications	Necroptosis Inhibitor
Formula	C₁₃H₁₁N₃
Molecular Weight	209.25
SMILES	C1=CC=C2C(=C1)C3=C(C4=NNC=C4CC3)N2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.