Fig. 1 · Structure
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Nemazoline
Nasal Decongestant
Nemazoline is a selective α-adrenergic agent that functions primarily as an α1-agonist and α2-antagonist, making it an effective nasal decongestant. Its mechanism involves α1-mediated contraction of capacitance vessels, which alleviates congestion while preserving blood flow due to its α2-antagonism. Additionally, Nemazoline inhibits the α2-mediated constriction of resistance vessels induced by endogenous noradrenaline, further enhancing its decongestant properties. It is widely utilized in research related to respiratory health and vascular responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Agonist |
| CAS Number | 130759-56-7 |
| Applications | Nasal Decongestant |
| Formula | C10H11Cl2N3 |
| Molecular Weight | 244.12 |
| Synonyms | A-57219 free base; SCH 40054 free base |
| SMILES | NC1=C(C=C(C=C1Cl)CC2=NCCN2)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.