Fig. 1 · Structure
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Neriifolin
Apoptosis Inhibitor
Neriifolin is a potent apoptosis inhibitor that primarily targets Na+, K+-ATPase. This CNS-penetrating cardiac glycoside disrupts the formation of LC3-associated phagosomes by interacting with beclin 1, which contributes to the suppression of experimental autoimmune encephalomyelitis (EAE) development. Additionally, Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells, making it a valuable reagent for cancer and neuroinflammatory research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 466-07-9 |
| Applications | Apoptosis Inhibitor |
| Formula | C30H46O8 |
| Molecular Weight | 534.68 |
| Synonyms | 17β-Neriifolin |
| SMILES | O[C@@]12[C@@]3([H])[C@@](CC[C@@]1([C@](C4=CC(OC4)=O)([H])CC2)C)([H])[C@@]5([C@](C[C@H](CC5)O[C@H]6[C@H]([C@@H]([C@H]([C@@H](O6)C)O)OC)O)([H])CC3)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.