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Nesiritide acetate

Catalog No.: A61965
NPRs Agonist
Nesiritide acetate is a recombinant human B-type natriuretic peptide that acts as an agonist of natriuretic peptide receptors (NPRs), exhibiting Kd values of 7.3 pM and 13 pM for NPR-A and NPR-C, respectively. This compound regulates the activation and inactivation of L-type calcium channels, demonstrating significant vasodilatory, diuretic, and natriuretic actions. It is primarily utilized in the research of cardiovascular conditions, particularly heart failure and vascular remodeling following arterial injury.
Nesiritide acetate 1684439-46-0 NPRs Agonist
Grouped product items
Size Price Stock Qty
1mg
$150.00
In stock
5mg
$675.00
In stock
10mg
$1,240.00
In stock
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionNesiritide acetate is a recombinant human B-type natriuretic peptide that acts as an agonist of natriuretic peptide receptors (NPRs), exhibiting Kd values of 7.3 pM and 13 pM for NPR-A and NPR-C, respectively. This compound regulates the activation and inactivation of L-type calcium channels, demonstrating significant vasodilatory, diuretic, and natriuretic actions. It is primarily utilized in the research of cardiovascular conditions, particularly heart failure and vascular remodeling following arterial injury.
Product Information
Catalog NumA61965
FormulaC145H248N50O44S4
Molecular Weight3524.09
CAS Number1684439-46-0
SequenceSPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (Disulfide bridge: Cys10-Cys26)
Sequence shorteningSer-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His (Disulfide bridge: Cys10-Cys26)
SMILESC(C)(O)=O.C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(NCC(N[C@@H]1C(=O)N[C@@H](CC2=CC=CC=C2)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CN=CN3)C(O)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CC(C)C)=O)[C@@H](C)C)=O)CCCCN)=O)CSSC1)[H])=O)=O)CO)=O)=O)CCC(N)=O)=O)[C@H](C)C)=O)CCSC)=O)CCCCN)(=O)[C@H]4N(C([C@H](CO)N)=O)CCC4
SynonymsBrain Natriuretic Peptide-32 human acetate; BNP-32 acetate
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GPCR/G Protein > Natriuretic Peptide Receptor (NPR)