Netupitant

Catalog No.: A14428

NK1 receptor antagonist

Netupitant

Netupitant Chemical Structure

CAS NO. 290297-26-6

Netupitant is a selective neurokinin 1 (NK1) receptor antagonist. It competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV).

Availability: In stock

Package Price Qty
5 mg

Regular Price: $40.00

Special Price $36.00

10 mg

Regular Price: $70.00

Special Price $63.00

25 mg

Regular Price: $150.00

Special Price $135.00

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

Netupitant is a selective neurokinin 1 (NK1) receptor antagonist. It competitively binds to and blocks the activity of the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV).
Targets
neurokinin 1 receptor
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.28 mL 86.42 mL 172.83 mL
0.5 mM 3.46 mL 17.28 mL 34.57 mL
1 mM 1.73 mL 8.64 mL 17.28 mL
5 mM 0.35 mL 1.73 mL 3.46 mL

*The above data is based on the productmolecular weight 578.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A14428
Actions Antagonist
M. Wt 578.59
Formula C30H32F6N4O
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 290297-26-6
Synonyms D05152, AG-E-94200
SMILES CC1=CC=CC=C1C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4CCN(CC4)C

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