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α-synuclein

α-Synuclein inhibitors and degraders act on a presynaptic protein that aggregates in Parkinson's disease. α-Synuclein (SNCA) is a small, natively unfolded protein that associates with membranes and synaptic vesicles. In 1997 a point mutation in its gene was found in families with inherited Parkinson's disease. The same year it was detected as a major component of Lewy bodies, the protein inclusions typical of the disease. Misfolded α-synuclein forms oligomers and amyloid fibrils, which are studied in aggregation assays, neuronal cells and transgenic animals. SynuClean-D and PBT434 mesylate are listed as aggregation inhibitors, minzasolmin as an oligomerization inhibitor and CLR01 sodium as a molecular tweezer. Proteolysis-targeting chimeras (PROTACs) such as PROTAC α-synuclein degrader 3 direct the protein to proteasomal degradation.

4 Items

  • PROTAC α-Synuclein/Tau degrader 1
    Cat. No.
    A79326
    CAS No.
    3032208-24-2

    PROTAC α-Synuclein/Tau degrader 1

    PROTAC α-Synuclein/Tau degrader 1 targets α-synuclein and tau for degradation through the ubiquitin-proteasome system. This dual PROTAC degrader demonstrates effective binding with dissociation constants of 0.47 μM and 2.78 μM for α-synuclein and tau, respectively, and has DC50 values of 1.57 μM and 4.09 μM. Its ability to penetrate the blood-brain barrier makes it a valuable tool for research into neurodegenerative diseases, particularly Parkinson's disease. The compound's design includes components for ligand binding and a linker optimized for efficient degradation.

    In stock View Details
    5 mg
    $210.00
    10 mg
    $340.00
    All 4 sizes
  • PROTAC α-synuclein degrader 5
    Cat. No.
    A79408
    CAS No.
    2781922-42-5

    PROTAC α-synuclein degrader 5

    PROTAC α-synuclein degrader 5 is a potent small-molecule degrader targeting α-synuclein aggregates through the PROTAC mechanism. This compound demonstrates a DC50 value of 7.51 μM and achieves a maximal degradation rate (Dmax) of 89%. Incorporating the probe molecule sery308 and E3 ligase ligands, this degrader is suitable for research on neurological diseases, facilitating studies on the pathophysiology of synucleinopathies.

    In stock View Details
    1 mg
    $215.00
    5 mg
    $445.00
    All 3 sizes
  • PROTAC α-synuclein degrader 3
    Cat. No.
    A79411
    CAS No.
    2412273-77-7

    PROTAC α-synuclein degrader 3

    PROTAC α-synuclein degrader 3 is a selective degrader targeting α-synuclein via the ubiquitin-proteasome system. This compound facilitates the ubiquitination and subsequent degradation of α-synuclein, making it a valuable tool for researching Parkinson's disease mechanisms. Its unique design incorporates specific ligands and linkers to optimize efficacy in targeted protein degradation, aiding investigations into therapeutic strategies for neurodegenerative disorders.

    In stock View Details
    1 mg
    $270.00
    5 mg
    $695.00
    All 5 sizes
  • α-Synuclein modulator 1
    Cat. No.
    A79453
    CAS No.
    3058709-40-0

    α-Synuclein modulator 1

    α-Synuclein modulator 1 is a selective modulator targeting α-synuclein, a protein implicated in neurodegenerative diseases such as Parkinson's. This compound exhibits optimal absorption and emission wavelengths of 386 nm and 603 nm, respectively, in a 1:1 acetonitrile/phosphate-buffered saline (PBS) solution. It is an invaluable tool for research applications focused on understanding α-synuclein's role in disease pathology and therapeutic development.

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    Out of stock

    All 3 sizes

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