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α-synuclein

α-Synuclein inhibitors and degraders act on a presynaptic protein that aggregates in Parkinson's disease. α-Synuclein (SNCA) is a small, natively unfolded protein that associates with membranes and synaptic vesicles. In 1997 a point mutation in its gene was found in families with inherited Parkinson's disease. The same year it was detected as a major component of Lewy bodies, the protein inclusions typical of the disease. Misfolded α-synuclein forms oligomers and amyloid fibrils, which are studied in aggregation assays, neuronal cells and transgenic animals. SynuClean-D and PBT434 mesylate are listed as aggregation inhibitors, minzasolmin as an oligomerization inhibitor and CLR01 sodium as a molecular tweezer. Proteolysis-targeting chimeras (PROTACs) such as PROTAC α-synuclein degrader 3 direct the protein to proteasomal degradation.

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  • α-Synuclein modulator 1
    Cat. No.
    A79453
    CAS No.
    3058709-40-0

    α-Synuclein modulator 1

    α-Synuclein modulator 1 is a selective modulator targeting α-synuclein, a protein implicated in neurodegenerative diseases such as Parkinson's. This compound exhibits optimal absorption and emission wavelengths of 386 nm and 603 nm, respectively, in a 1:1 acetonitrile/phosphate-buffered saline (PBS) solution. It is an invaluable tool for research applications focused on understanding α-synuclein's role in disease pathology and therapeutic development.

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