Catechol-O-Methyltransferase (COMT)

Cat. No.

A29564

CAS No.

18525-25-2

Serotonin maleate

Synonyms: 5-Hydroxytryptamine maleate; 5-HT maleate

Serotonin maleate acts as a selective agonist for 5-HT receptors in the central nervous system, influencing various physiological processes, including mood regulation and cognitive function. Additionally, it serves as a catechol O-methyltransferase (COMT) inhibitor with a Ki value of 44 μM, making it valuable for research involving neurotransmitter dynamics and the modulation of serotonergic pathways. Its multiple biological activities position it as a critical reagent for studies in neuroscience and pharmacology.

Cat. No.

A44570

CAS No.

2115701-43-2

3-BTMD

3-BTMD is a fluorescent compound generated through the action of the COMT enzyme on its substrate, 3-BTD, exhibiting an excitation wavelength of 390 nm and an emission wavelength of 510 nm. This reagent is primarily utilized in fluorescent labeling and imaging applications, facilitating the study of enzymatic activity and biomolecular interactions in various biological contexts. Its distinct fluorescence properties make it a valuable tool for researchers in the fields of biochemistry and molecular biology.

Cat. No.

A49895

CAS No.

2518151-57-8

Comtifator

Synonyms: BMS-986419; EVT-8683; EOAI-4018683

Comtifator is an integrated stress response pathway modulator that influences cellular responses to various stressors. This compound is essential for studying the role of the integrated stress response in diseases such as neurodegeneration and cancer. Its ability to alter stress signaling makes it a valuable tool for research investigating therapeutic interventions and mechanisms underlying stress-related disorders.

Cat. No.

A69651

CAS No.

200630-46-2

3-O-Methyldopa monohydrate

Synonyms: 3-Methoxy-L-tyrosine monohydrate; 3-O-Methyl-L-DOPA monohydrate

3-O-Methyldopa monohydrate is a notable metabolite of L-DOPA, primarily interacting with catechol O-methyltransferase (COMT). It does not function as a substrate or inhibitor of L-amino acid decarboxylase, distinguishing it from its precursor. The inhibition of COMT by this compound may enhance the therapeutic effects of L-DOPA in Parkinson's disease, making it a valuable tool in neurological research and studies on Parkinson's treatments.

Cat. No.

B21621

CAS No.

50-67-9

Serotonin

Synonyms: 5-Hydroxytryptamine; 5-HT

Serotonin is a monoamine neurotransmitter that acts as an endogenous agonist at 5-HT receptors. It plays a critical role in various physiological processes, including mood regulation and cognitive function. Additionally, serotonin functions as a catechol O-methyltransferase (COMT) inhibitor, exhibiting a Ki value of 44 μM. This compound is essential for studies related to neuroscience, pharmacology, and the understanding of mood disorders.