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Catechol-O-Methyltransferase (COMT)

Catechol-O-methyltransferase (COMT) inhibitors block an enzyme that inactivates catecholamines such as dopamine. COMT transfers a methyl group from S-adenosylmethionine (SAM) to one hydroxyl group of the catechol ring. Enzymatic O-methylation of epinephrine and related catechols was first described in 1958. The enzyme converts dopamine into 3-methoxytyramine, a metabolite also listed here as 3-methoxyTyramine HCl. A common functional polymorphism, reported in 1996, lowers COMT activity and is studied in neuropsychiatric research. Entacapone, tolcapone, opicapone and nebicapone are nitrocatechol inhibitors used to study catecholamine and levodopa metabolism. The listing also includes related monoamine compounds such as serotonin maleate.

2 Items

  • Serotonin maleate
    Cat. No.
    A29564
    CAS No.
    18525-25-2

    Serotonin maleate

    Synonyms: 5-Hydroxytryptamine maleate; 5-HT maleate

    Serotonin maleate acts as a selective agonist for 5-HT receptors in the central nervous system, influencing various physiological processes, including mood regulation and cognitive function. Additionally, it serves as a catechol O-methyltransferase (COMT) inhibitor with a Ki value of 44 μM, making it valuable for research involving neurotransmitter dynamics and the modulation of serotonergic pathways. Its multiple biological activities position it as a critical reagent for studies in neuroscience and pharmacology.

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  • Serotonin
    Cat. No.
    B21621
    CAS No.
    50-67-9

    Serotonin

    Synonyms: 5-Hydroxytryptamine; 5-HT

    Serotonin is a monoamine neurotransmitter that acts as an endogenous agonist at 5-HT receptors. It plays a critical role in various physiological processes, including mood regulation and cognitive function. Additionally, serotonin functions as a catechol O-methyltransferase (COMT) inhibitor, exhibiting a Ki value of 44 μM. This compound is essential for studies related to neuroscience, pharmacology, and the understanding of mood disorders.

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    1 mg
    $20.00
    5 mg
    $50.00
    All 6 sizes

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