NF157

Name: NF157
Brand: Adooq Bioscience
SKU: A62814
Rating: 5 (288 reviews)

Catalog No.: A62814

P2Y11 Antagonist

NF157 is a selective antagonist of the P2Y11 receptor, exhibiting a pKi of 7.35 and an IC50 of 463 nM. It demonstrates high specificity, with significantly higher IC50 values for related receptors P2Y1 and P2Y2. NF157 is known to reduce the expression of metalloproteinases (MMP)-3 and MMP-13, making it a valuable tool for research into osteoarthritis and related inflammatory conditions.

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Grouped product items
Size	Price	Stock
1mg	$225.00	In stock
5mg	$460.00	In stock
10mg	$755.00	In stock
25mg	$1,355.00	In stock
Bulk Size	Bulk Discount

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Biological Activity

Description	NF157 is a selective antagonist of the P2Y11 receptor, exhibiting a pKi of 7.35 and an IC50 of 463 nM. It demonstrates high specificity, with significantly higher IC50 values for related receptors P2Y1 and P2Y2. NF157 is known to reduce the expression of metalloproteinases (MMP)-3 and MMP-13, making it a valuable tool for research into osteoarthritis and related inflammatory conditions.

Product Information

Catalog Num	A62814
Formula	C49H28F2N6Na6O23S6
Molecular Weight	1437.10
CAS Number	104869-26-3
SMILES	O=C(NC1=CC(C(NC2=CC(C(NC3=CC=C(S(=O)(O[Na])=O)C4=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C34)=O)=CC=C2F)=O)=CC=C1)NC5=CC(C(NC6=CC(C(NC7=CC=C(S(=O)(O[Na])=O)C8=CC(S(=O)(O[Na])=O)=CC(S(=O)(O[Na])=O)=C78)=O)=CC=C6F)=O)=CC=C5

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