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Form	MW
NGD 98-2 hydrochloride This page	435.87
NGD 98-2	399.41

NGD 98-2 hydrochloride

CRF-1 Receptor Antagonist

NGD 98-2 hydrochloride is an orally active antagonist of the corticotropin-releasing factor-1 (CRF-1) receptor. This compound demonstrates significant inhibition of CRF-1 receptor activity, making it valuable for research into stress-related disorders and neuropsychiatric conditions. Its ability to modulate the hypothalamic-pituitary-adrenal (HPA) axis highlights its potential utility in understanding the pathophysiology of anxiety and depression.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	1780390-58-0
Applications	CRF-1 Receptor Antagonist
Formula	C₁₉H₂₅ClF₃N₃O₃
Molecular Weight	435.87
SMILES	CC1=NC(NC(CC)CC)=C(N=C1C2=CC=C(C=C2OC)OC(F)(F)F)OC.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.