NH-3 is a reversible antagonist of the thyroid hormone receptor (THR) with an IC50 of 55 nM. It effectively inhibits the binding of thyroid hormones to their receptor, consequently preventing cofactor recruitment. Additionally, NH-3 serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This compound is useful in studies related to thyroid function and receptor signaling pathways.
NH-3 is a reversible antagonist of the thyroid hormone receptor (THR) with an IC50 of 55 nM. It effectively inhibits the binding of thyroid hormones to their receptor, consequently preventing cofactor recruitment. Additionally, NH-3 serves as a click chemistry reagent due to its alkyne group, enabling copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This compound is useful in studies related to thyroid function and receptor signaling pathways.
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