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NH2-cX-R-L-S-X-K-G-P-(D-1Nal)

APJ Agonist

NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) is a potent APJ agonist that effectively interacts with the Gαi1 protein, displaying an EC50 value of 0.8 nM. This compound also recruits β-arrestin2 with an EC50 of 31 nM, highlighting its significant downstream signaling capabilities. Additionally, NH2-c[X-R-L-S-X]-K-G-P-(D-1Nal) demonstrates prolonged cardiac effects, making it valuable for studies related to cardiovascular research and APJ receptor biology.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Agonist
CAS Number	2891469-80-8
Applications	APJ Agonist
Formula	C₄₉H₇₃N₁₃O₁₁
Molecular Weight	1020.18
SMILES	N[C@@H]1C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N2CCC[C@H]2C(N[C@H](CC3=C4C=CC=CC4=CC=C3)C(O)=O)=O)=O)=O)CCCCN)=O)C/C=C\C1)=O)CO)=O)CC(C)C)=O)CCCNC(N)=N)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.