Fig. 1 · Structure
Documents & Downloads
NH2-C4-NH-Boc
PROTAC Linkers
NH2-C4-NH-Boc is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an alkyl/ether structure, facilitating the connection of two distinct ligands: one targeting an E3 ubiquitin ligase and the other directed at the protein of interest. By harnessing the ubiquitin-proteasome system, PROTACs constructed with NH2-C4-NH-Boc enable selective degradation of specific target proteins, making it a valuable reagent for research in targeted protein degradation and drug development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 68076-36-8 |
| Applications | PROTAC Linkers |
| Formula | C9H20N2O2 |
| Molecular Weight | 188.27 |
| SMILES | NCCCCNC(OC(C)(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.