Fig. 1 · Structure
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NH2-NODAGA TFA
Bifunctional Chelator
NH2-NODAGA TFA is a bifunctional chelator designed for the coordination of radionuclides, facilitating the development of radionuclide conjugates (RDCs). It can be reacted with diethyl squarate in a 0.5M phosphate buffer at room temperature, yielding NODAGA.SA, which effectively targets the L-lysine urea-L-glutamate (KuE) moiety associated with prostate-specific membrane antigen (PSMA). The complex NODAGA.SA.KuE demonstrates the ability to bind [68]Ga, making it valuable for positron emission tomography (PET) imaging in research involving NMRInu/nu nude mice with LNCaP tumors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 3053227-80-5 |
| Applications | Bifunctional Chelator |
| Formula | C19H32F3N5O9 |
| Molecular Weight | 531.48 |
| SMILES | O=C(CN1CCN(CCN(C(CCC(NCCN)=O)C(O)=O)CC1)CC(O)=O)O.O=C(O)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.