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NH2-NODAGA

Bifunctional Chelator

NH2-NODAGA is a bifunctional chelator based on the NODAGA framework that effectively binds to radionuclides for the preparation of radionuclide conjugates (RDCs). This compound can react with diethyl squarate in a 0.5M phosphate buffer to yield NODAGA.SA, which is capable of targeting L-lysine urea-L-glutamate (KuE), an important component of prostate-specific membrane antigen (PSMA). The NODAGA.SA.KuE complex can be used for [68Ga] labeling, facilitating PET imaging in NMRInu/nu nude mice bearing LNCaP tumors, thereby advancing research in cancer diagnostics and therapy.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1630114-57-6
Applications	Bifunctional Chelator
Formula	C₁₇H₃₁N₅O₇
Molecular Weight	417.46
SMILES	O=C(CN1CCN(CCN(C(CCC(NCCN)=O)C(O)=O)CC1)CC(O)=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.